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Systemic Enzymes

Our PureZyme and PureZyme Plus offer systemic enzyme options to support circulation, fight inflammation, remove toxins, and boost immune health*

DigestZyme digestive enzymes Protease only formula for those new to systemic enzyme therapy.


Product details

120 Capsules



PureZyme Plus


Potent blend of Protease and Bromelain with highly active pH range essential for gastric stability.

Compare to Transformation Professional Protocol (TPP) Protease.

Product details

PureZyme Plus
60 caps


How Proteases Support Immune Health from Transformation Enzymes on Vimeo.

Questions about Systemic Enzymes

When is the best time to take a protease supplement?
For maximum systemic benefit, it is best to take proteases between meals as this allows for faster absorption into circulation. However, if this is not realistic for your patient, then it is ok to take proteases with meals knowing that some of the protease enzymes may be used to digest food proteins. Also, it is better to take small doses several times throughout the day rather than one or two large doses in a day. Common dosing times are first thing in the morning, mid-morning, mid-afternoon, and bedtime.

Can protease enzymes be taken with NSAIDS and/or prescription medications?
Digestive enzymes function by breaking down specific chemical bonds in foods. In most cases digestive enzymes can therefore safely be taken with medications. However, it is of course always recommended to let your health care provider know what you are taking.

Can protease enzymes be taken with prescription blood thinners?
One area of caution is with prescription blood thinning agents. These types of prescription drugs interfere with the natural blood clotting mechanisms, while proteases break down fibrin allowing for better blood flow. They can be taken in conjunction, but it is recommended to dose them about four hours apart and monitor lab work closely. We recommend notifying and working with the doctor prescribing the medications.

Can you take protease enzymes when taking prescription “protease inhibitors”?
More often than not, the term “protease” that describes proteolytic enzymes is used in very general terms. There are many metabolic proteases in our body, each with many different functions. The medications that are designed as protease inhibitors are targeting a very specific viral protease. The supplemental digestive proteases are very different and will not interfere with the medication. In fact, oral supplemental digestive enzymes can be very supportive to those patients with auto-immune disorders.


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* Statements have not been evaluated by the Food and Drug Administration (FDA). Products not intended to diagnose, treat, cure, or prevent any disease.

The information contained here is for reference only and is not intended to diagnose disease or prescribe treatment. The information contained herein is in no way to be considered a substitute for consultation with a health care professional. Furthermore, this information is for the private use of our clients and is not to be used publicly, reproduced, or distributed without the written consent of Enzyme Essentials, LLC

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